• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2020 Fiscal Year Annual Research Report

Investigating the mechanism to regulate osteocytes by circadian rhythm that effected by the crosstalk with periodontal ligament cells

Research Project

Project/Area Number 19J11906
Research InstitutionOkayama University

Principal Investigator

王 紫儀  岡山大学, 医歯薬学総合研究科, 特別研究員(DC2)

Project Period (FY) 2019-04-25 – 2021-03-31
KeywordsOsteocytes
Outline of Annual Research Achievements

骨細胞の細胞間コミュニケーションが骨代謝に与える研究を始めました。そして、細胞間コミュニケーション速度を定量的に測る方法を確立し、著名なSpringer社のプロトコルブックシリーズ(Methods in Molecular Biology)から招待を受けました。また、骨細胞の機械刺激応答の研究を進め、その応答は細胞間コミュニケーション速度に依存していることを突き止めました。さらに、骨細胞が機械的刺激を感知するために重要な候補遺伝子とその経路を、公開遺伝子チップデータを使ったバイオインフォマティクス解析を行い、低酸素症、概日リズム、エネルギー代謝に関わる遺伝子が骨細胞の機械刺激応答に重要な役割を果たすことを明らかにしました。そして、エネルギー代謝の時空間的パターンが、機械的刺激に応答して骨と他の臓器系との間の相互作用を調節する新たな可能性を示唆することができました。よって、期待以上の進展があったことをご報告致します。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

  • Research Products

    (8 results)

All 2021 2020

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Endonuclease increases efficiency of osteoblast isolation from murine calvariae2021

    • Author(s)
      Asano Yosuke、Matsumoto Yoshinori、La Rose Jose、He Fang、Katsuyama Takayuki、Ziyi Wang、Tsuji Shigetomo、Kamioka Hiroshi、Rottapel Robert、Wada Jun
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 1-8

    • DOI

      10.1038/s41598-021-87716-8

    • Peer Reviewed / Open Access
  • [Journal Article] Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes2020

    • Author(s)
      Wang Ziyi、Weng Yao、Ishihara Yoshihito、Odagaki Naoya、Ei Hsu Hlaing Ei、Izawa Takashi、Okamura Hirohiko、Kamioka Hiroshi
    • Journal Title

      PeerJ

      Volume: 8 Pages: e10244~e10244

    • DOI

      10.7717/peerj.10244

    • Peer Reviewed / Open Access
  • [Journal Article] Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading2020

    • Author(s)
      Osumi Ryuta、Wang Ziyi、Ishihara Yoshihito、Odagaki Naoya、Iimura Tadahiro、Kamioka Hiroshi
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 39 Pages: 148~159

    • DOI

      10.1007/s00774-020-01135-9

    • Peer Reviewed
  • [Journal Article] N-(3-oxododecanoyl)-homoserine lactone regulates osteoblast apoptosis and differentiation by mediating intracellular calcium2020

    • Author(s)
      Guo Jiajie、Wang Ziyi、Weng Yao、Yuan Haoze、Yoshida Kaya、Ikegame Mika、Uchibe Kenta、Kamioka Hiroshi、Ochiai Kazuhiko、Okamura Hirohiko、Qiu Lihong
    • Journal Title

      Cellular Signalling

      Volume: 75 Pages: 109740~109740

    • DOI

      10.1016/j.cellsig.2020.109740

    • Peer Reviewed
  • [Journal Article] The Analysis of Gap Junctional Intercellular Communication Among Osteocytes in Chick Calvariae by Fluorescence Recovery After Photobleaching2020

    • Author(s)
      Wang Ziyi、Ishihara Yoshihito、Kamioka Hiroshi
    • Journal Title

      Methods in Molecular Biology

      Volume: ー Pages: 1-9

    • DOI

      10.1007/7651_2020_322

    • Peer Reviewed
  • [Journal Article] The expression and regulation of Wnt1 in tooth movement-initiated mechanotransduction2020

    • Author(s)
      Ei Hsu Hlaing Ei、Ishihara Yoshihito、Odagaki Naoya、Wang Ziyi、Ikegame Mika、Kamioka Hiroshi
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 158 Pages: e151~e160

    • DOI

      10.1016/j.ajodo.2020.08.006

    • Peer Reviewed
  • [Journal Article] Outer membrane vesicles derived from Porphyromonas gingivalis induced cell death with disruption of tight junctions in human lung epithelial cells2020

    • Author(s)
      He Yuhan、Shiotsu Noriko、Uchida-Fukuhara Yoko、Guo Jiajie、Weng Yao、Ikegame Mika、Wang Ziyi、Ono Kisho、Kamioka Hiroshi、Torii Yasuhiro、Sasaki Akira、Yoshida Kaya、Okamura Hirohiko
    • Journal Title

      Archives of Oral Biology

      Volume: 118 Pages: 104841~104841

    • DOI

      10.1016/j.archoralbio.2020.104841

    • Peer Reviewed
  • [Presentation] Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes2020

    • Author(s)
      Wang Ziyi、Weng Yao、Ishihara Yoshihito、Odagaki Naoya、Ei Hsu Hlaing Ei、Izawa Takashi、Okamura Hirohiko、Kamioka Hiroshi
    • Organizer
      ASBMR 2019 Annual Meeting
    • Int'l Joint Research

URL: 

Published: 2021-12-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi