2022 Fiscal Year Final Research Report
Clarifying the mechanism of bone mechanical adaptation based on in silico observation of bone metabolic dynamics
| Project/Area Number |
19K04074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 18010:Mechanics of materials and materials-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 骨代謝 / 骨リモデリング / 力学的適応 / in silico実験 / バイオメカニクス |
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| Outline of Final Research Achievements |
To clarify the mechanism of bone mechanical adaptation through bone metabolism and remodeling, in this study, we developed a computer simulation platform to simultaneously observe the behaviors of molecules, cells, tissues, and organs in response to mechanical loading. First, we quantitatively evaluated the mechanical stimuli applied to osteocytes buried in bone tissue by fluid-structure interaction analysis. Then, we constructed a mathematical model of cortical-to-cancellous bone transformation, which is considered to be the main cause of age-related bone loss, and clarified its mechanism through remodeling simulation. Furthermore, we developed a mathematical model of bone metabolism that couples the dynamics of bone cells and the evolution of bone microdamage. The remodeling simulations using this mathematical model enabled the evaluation of the load-bearing function of cancellous bone from the viewpoints of bone quantity and quality.
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| Free Research Field |
生体力学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で構築した骨代謝・リモデリングのシミュレーション基盤は、力学的負荷に応じて骨組織内部で生じる細胞間シグナル伝達、個々の骨構成細胞動態、骨形態変化をコンピュータ上で同時観察することが可能であり、分子や細胞の３次元的な力学的・生化学的状態とそれらの時間変動を含めた４次元的な時空間情報を基に、組織や器官の力学的適応機構を統合的に理解するための新しい研究アプローチを提供するものである。また、網羅的な薬剤評価や効果的な投薬方針の策定などを促す臨床支援ツールとして、将来の医療への多大な貢献が期待される。
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