A Study on Blood Flow Rebalancing and Thrombosis Formation Caused by Patent Ductus Arteriosus

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K04181
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 19010:Fluid engineering-related
• Research Institution: Gifu National College of Technology
• Principal Investigator: Yamamoto Takahisa 岐阜工業高等専門学校, その他部局等, 准教授 (10345960)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 数値流体力学解析 / 血行動態 / 流体構造連成解析 / 動脈管

Outline of Final Research Achievements

Hypoplastic left heart patients have significant blood flow unbalance in the cardiovascular system; excess blood flows from the right ventricles to the lung. Patent Ductus Arteriosus (PDA) stenting prevents excess blood flow and shunts the blood flow to the aorta through PDA. This study elucidated the hemodynamics of the aorta-pulmonary artery system experimentally and numerically. This study carried out Particle Image Velocimetry measurement and Computational Fluid Dynamics analysis for three patient-specific models. The analysis clarified transient hemodynamics in the aorta-pulmonary artery system; pulmonary blood flow was shunt to the aorta at the peak systole and diastole. Q-criterion, which indicates the second-order invariant of turbulence flow, was generated in the PDA at the same period. This study found the influence of PDA morphology on transient hemodynamics. These flow characteristics are essential factors in thrombus formation in PDA.

Free Research Field

熱流体力学

Academic Significance and Societal Importance of the Research Achievements

本研究の特徴は，臨床的にしか検討されてこなかった大動脈-動脈管-肺動脈系の血行動態および血流リバランスを，工学的アプローチ（数値流体力学(CFD)解析，実症例のCTデータからの大動脈-動脈管-肺動脈系の生体模型の製作，PIV計測）により明らかにする点にある。これら工学的アプローチにより，動脈管開大による血流のリバランスメカニズム，動脈管径（PDAステントによる開大度合いに相当），拍動パラメータが動脈管まわりの血行動態に及ぼす影響を明らかにした。これら研究成果により，症例特有の血流リバランスを評価，予測することが可能となる。