2021 Fiscal Year Final Research Report
Three-dimensional accumulation of biological components based on sol-gel reaction using AC electrolysis and its biomedical applications
Project/Area Number |
19K05031
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 26030:Composite materials and interfaces-related
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Research Institution | Okayama University |
Principal Investigator |
Yoshioka Tomohiko 岡山大学, ヘルスシステム統合科学学域, 准教授 (50452016)
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Co-Investigator(Kenkyū-buntansha) |
城崎 由紀 九州工業大学, 大学院工学研究院, 准教授 (40533956)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | ゾル-ゲル / 電気分解 / 交流 |
Outline of Final Research Achievements |
The purpose of this study was to develop a technology to accumulate biological components, such as cells and proteins, three-dimensionally by incorporating them into scaffold materials formed by the sol-gel reaction of silicon alkoxides under the application of AC electric fields. It was demonstrated that cell models (polystyrene beads similar in size and charge to cells) or proteins can be incorporated into silica gels formed under AC electric fields. Furthermore, novel bioactive gels obtained by the sol-gel reaction under AC electric fields were developed as scaffold materials.
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Free Research Field |
バイオマテリアル
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Academic Significance and Societal Importance of the Research Achievements |
本研究において、交流電場下で生体成分の集積の足場となる無機ゲルを形成させつつ、細胞モデルやタンパク質が電場を用いて集積できることを明らかにした。これは無機ゲルを足場材料とした生体成分の三次元集積を可能にする新しいプロセスである。再生医療技術や、細胞を複合化したデバイス、バイオセンサなどの新しいプロセッシングとして期待できる。
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