2021 Fiscal Year Final Research Report
Mechanism elucidation of long-term antibacterial property arrised in titanium based biomaterial
| Project/Area Number |
19K05059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 26040:Structural materials and functional materials-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
関野 徹 大阪大学, 産業科学研究所, 教授 (20226658)
後藤 知代 大阪大学, 産業科学研究所, 准教授 (60643682)
小正 聡 大阪歯科大学, 歯学部, 講師 (70632066)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 抗菌 / 紫外光 / チタン |
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| Outline of Final Research Achievements |
To clarify the mechanism of the long-term antibacterial properties realized at titanium surface after (V)UV irradiation, we started to understand the wavelength dependence on this phenomena. The following three types of UV treatment methods were prepared. (1) simultaneously irradiates the 185 nm and 254 nm line spectra of a low-pressure Hg lamp, (2) cuts 185 nm light and irradiates only 254 nm light, and (3) irradiates the 172 nm band spectrum emitted by the Xe excimer lamp.
As a result, almost no dead bacteria were observed in untreated titanium and (2) case, and in (1) and (3), strong antibacterial activity was confirmed after 24 hours of antibacterial action time. It is considered that the antibacterial effect was exhibited by post-UV irradiation as a phenomenon due to the influence of vacuum ultraviolet light.
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| Free Research Field |
光科学（光発生と光利用）、材料科学
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| Academic Significance and Societal Importance of the Research Achievements |
VUV光照射後では、“有意に抗菌”と認められる2Logレベル以上の抗菌性がチタン表面に発現する、この材料科学的なメカニズムの全貌は未だ憶測の域を出ていないが、抗菌を誘起する、現象をスタートさせる波長は、200nm以下の光であることがわかった。チタン（合金）製の医療用インプラント等は経時変化で生体親和性に劣化を来すが、これをUV-C光で元の活性表面に戻す光機能化技術(ＰＦ)が発明され、骨芽細胞など生体組織との初期親和性を確保する手段とされている。即ち、本研究で得たVUV光照射による抗菌性の発現は、200nm以上の光で起こるＰＦとは異なる。医療現場での光の利用法が１つ、加わったかもしれない。
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