2021 Fiscal Year Final Research Report
Shape and size control of tannic acid-PEG complex and application to vaccine
| Project/Area Number |
19K05217
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 28030:Nanomaterials-related
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| Research Institution | Nippon Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | サブミクロン粒子 / アガロース |
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| Outline of Final Research Achievements |
We found that agarose-based submicron particles were obtained easily by mixing TA and heated-agarose. When a large excess of TA to agarose was used for complex formation, a stable Aga-TA complex was obtained, indicating that TA acts as an inhibitor of agarose gel formation as well as a dispersant of Aga-TA complexes to give good dispersibility. Aga-TA complexes showed a two-step thermal response, with TA released from the complex during the first transition by heating to 50°C. TA provides not only its own drug functionality, but also the ability to retain various drugs for delivery in particles due to its high affinity to various molecules. Thus, our findings are expected to lead to new applications that utilize natural agarose as particles (e.g., as drug delivery carriers) having a release function.
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| Free Research Field |
生体機能材料
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の遂行時はコロナ禍と重なっており、ワクチンの重要性が再認識された時期である。本研究は将来的にワクチンの効果を高めるための生体適合性の高い粒子の作製を目指した。この粒子は抗原や核酸を運搬し、免疫細胞に届けることを目的としている。ワクチン運搬時もできる限り冷蔵から室温において保存できることが望ましく、アガロースとタンニン酸からなる粒子のもつ安定した水中での分散性と生体適合性の両立はそれらの課題解決につながる可能性がある。またアガロースの粒子化はワクチンに限らず、広く多糖の生体材料としての応用範囲を広げるものである。
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