2022 Fiscal Year Final Research Report
A study of self-assembling patterns of Prussian blue and its analogues for their application to pulsatile drug delivery systems
| Project/Area Number |
19K05409
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 32020:Functional solid state chemistry-related
|
|---|
| Research Institution | Japan Women's University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2023-03-31
|
| Keywords | プルシアンブルー類似体 / セシウム吸着剤 / リーゼガングバンド / 反応－拡散系 / 徐放性製剤 |
|---|
| Outline of Final Research Achievements |
This research newly developed a laboratory-use high-resolution X-ray fluorescence spectrometer to analyze the precipitation patterns of manganese (Mn)-iron based Prussian-blue analogs (Mn-Fe PBA) that spontaneously formed in agarose gel, clarifying (1) the appropriate preparation conditions to generate periodic precipitation banding of Mn-Fe PBA (which is potentially applicable as Cs adsorbent for oral delivery), (2) the concentration distributions of Mn-Fe PBA in the periodic bands, (3) the local atomic structure around Mn atoms, and (4) their high Cs adsorption and its mechanism.
|
| Free Research Field |
物理化学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究は、アガロース中で自発的に形成されるマンガン-鉄系のPBA（Mn-Fe PBA）の周期的沈殿現象が、放射性セシウムの吸着・除去に有効利用できることをはじめて示した。この成果は、環境科学や放射線医学に貢献するだけでなく、自発的なパターン形成の材料科学への応用としても興味深い。加えて、本研究の中で新たに見いだされた２種類の反応と拡散による新規な沈殿パターン形成現象は、非平衡系の物理学に新たな研究領域を提供した。このように本研究は、基礎・応用両面の様々な研究領域に新たな刺激を与えた。
|
