Synthesis and Functional Expression of Molecular Brakes with Rotaxane Framework

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05442
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 33010:Structural organic chemistry and physical organic chemistry-related
• Research Institution: Tokyo University of Science
• Principal Investigator: Saito Shinichi 東京理科大学, 理学部第一部化学科, 教授 (80283076)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ロタキサン / 動的挙動 / 分子マシン

Outline of Final Research Achievements

Rotaxane is an important structure for the future development of molecular machine, and it consists of a ring component and an axle component, which are not connected by covalent bond. In this study we synthesized a new rotaxane with a regulated rotation.
We previously developed an efficient and unique method for the synthesis of rotaxane. We applied this method for the synthesis of the target molecule, which is a rotaxane with a rigid axle component and bulky triaryl moiety. We succeeded in the synthesis of the target molecule and studied the dynamic behavior of the rotaxane. We found that this molecule does not function as a molecular break under the conditions we studied.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

研究代表者らの合成手法を活用することにより、高度に官能基化されたロタキサンが合成可能であることを示した。また、分子構造と機能発現の関係について新たな知見を得ることができた。今回合成に成功したロタキサンは分子マシン（分子単位でモーターなどの機能を発現する分子）の開発において有望な化合物群であると考えられており、このような研究を進めることは将来の分子マシン創製に向け、大きな意義を有するものである。