2021 Fiscal Year Final Research Report
Mechanistic analysis and reaction control of ionizable drugs and their conjugates with dendritic polymers in a biomimetic membrane system
| Project/Area Number |
19K05541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | アントラサイクリン / デンドリマー / 液液界面 / 凝集誘起発光 / 分光電気化学 |
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| Outline of Final Research Achievements |
The membrane surface and transmembrane processes of ionizable drugs including anthracycline antibiotics were studied spectroelectrochemically at liquid-liquid interfaces as a model of biomembrane. The aggregation-induced emission mechanism of water-soluble tetraphenyl ethene derivatives was also elucidated at liquid-liquid and biomimetic interfaces. The ion association of ionizable drugs with dendrimers and its interfacial mechanism were studied for evaluating the capability of dendrimers as functional drug carrier.
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| Free Research Field |
界面分析化学，分光電気化学
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| Academic Significance and Societal Importance of the Research Achievements |
モデル反応場を用いてイオン性薬剤の生体膜における表面吸着や膜透過反応の機構を解析する方法論を示し，薬剤の分子構造と薬物動態の相関を検討する上で重要な知見を得た。また、多分岐高分子との複合化による薬剤の相間分配挙動の制御に限定的ながら成功し，多分岐高分子がドラッグデリバリーのための薬剤キャリアとして有用であること確認した。さらに液液界面や膜表面で選択的に生じる凝集誘起発光の反応系を見いだし，膜表面を対象とした電位感受性蛍光プローブとして応用できる可能性を示した。
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