Redesign of the Petasis reaction aiming facile polymeric amino acid synthesis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05578
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 35010:Polymer chemistry-related
• Research Institution: Gunma University
• Principal Investigator: Kakuchi Ryohei 群馬大学, 大学院理工学府, 助教 (00743816)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 多成分連結反応 / 高分子反応 / アミノ酸

Outline of Final Research Achievements

In the research, we aimed at optimizing and re-designing the Petasis three-component reaction (Petasis-3CR). The original Petasis-3CR refers to the reaction between aromatic boronic acids, amines, and glyoxylic acids. This research focused on the feasible optimization of the Petasis-3CR so that its integration with polymer synthesis will be enabled. For this, we have employed protected boronic acids to bypass the synthetic limitations arising from the polymers bearing boronic acids. Building on the modification we achieved in this work, the Petasis-3CR is allowed to be integrated with polymer synthesis, thereby providing poly (α-amino acids).

Free Research Field

高分子化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、従来合成が困難であったポリ（α-アミノ酸）を多様性志向的に合成することを可能とした。ポリ（α-アミノ酸）はその化学構造から、例えばアンチファウリング材料や有機触媒といった様々な材料分野への展開が期待される。