Development of glycoclusters based on the protecting-group-free synthesis of glycopolymers in water

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05580
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 35010:Polymer chemistry-related
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: Tanaka Tomonari 京都工芸繊維大学, 繊維学系, 准教授 (70585695)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 糖鎖高分子 / 水中合成 / 水溶性活性エステル / 糖鎖 / ラジカル重合

Outline of Final Research Achievements

The purpose in this study is development of novel polymers bearing water-soluble activated ester moieties and their use for the synthesis of oligosaccharide-grafted polymers in water. Novel acrylamide derivatives bearing a water-soluble activated ester moiety were synthesized as monomers and subjected to RAFT polymerization to obtain polymers bearing water-soluble activated ester moieties. The stability of the monomers and polymers in water were evaluated. The resulting polymers, which were stable in water, were reacted with a sialylglycopeptide (SGP) by a post-polymerization modification in water to obtain SGP-grafted glycopolymers.

Free Research Field

高分子化学

Academic Significance and Societal Importance of the Research Achievements

合成高分子の側鎖に多数の糖分子が結合した構造の機能性高分子のひとつである糖鎖高分子は、原料の入手が容易で合成化学的に取り扱いが容易な単糖や二糖などのモデル化合物での報告がほとんどであり、複雑な構造を有するオリゴ糖鎖を用いた例は極めて少ない。さらに、糖の良溶媒である水を溶媒とした水中での糖鎖高分子合成は、昨今の環境負荷低減にも合致する。本研究では、水中で糖鎖高分子をはじめとする機能性高分子の合成に利用できる新規なポリマーを開発した。