2021 Fiscal Year Final Research Report
Development of a novel precise polycondensation using active site recirculating catalysts
Project/Area Number |
19K05583
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 35010:Polymer chemistry-related
|
Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
ANDO Tsuyoshi 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 (60324654)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Keywords | 精密重合 / 重縮合 / アミノ酸 / 触媒 / ペプチド / ヒドロキシベンゾトリアゾール |
Outline of Final Research Achievements |
In this study, we proposed a bifunctional catalyst with a cyclic mechanism for polycondensation in which the positions of the activation site at the growth end and the monomer capture site are interchanged, and aimed to proof a new control concept in polycondensation. The bifunctional catalyst was synthesized by using a hydroxybenzotriazole (HOBt) group as the catalytic moiety and linking two molecules with spacers of different chain lengths. The resulting bifunctional catalyst was introduced with an acetyl group as a polymerization initiating group (starting end group) and L-proline (L-Pro) was polymerized using the bifunctional catalysts. In particular, when the polymerization was carried out at 4°C in a water/acetonitrile mixture, poly(L-Pro) with a molecular weight of about 2,000 and a molecular weight dispersion of about 1.2 was successfully obtained, suggesting that the bifunctional catalyst is effective in controlling polymerization.
|
Free Research Field |
高分子化学
|
Academic Significance and Societal Importance of the Research Achievements |
ポリマーの構造制御合成技術は高機能、高性能ポリマー材料の開発における極めて重要な基盤技術である。連鎖重合では多くの制御重合系が見出されてきたのに対し、重縮合など逐次重合の制御は一部の系に限定されており、新たな精密重合技術の開発が望まれている。申請者が提案した活性部位循環型触媒は、逐次重合の制御を困難にする重合部位のランダムな反応の問題を解決し、反応点をポリマーの成長末端のみに限定することが期待できた。触媒合成の開拓、反応条件、高分子量化の検討など解決すべき問題は残されているものの、新しい逐次重合制御技術の可能性が示され、将来はこれを基盤とした技術により新たな材料開発への展開が期待される。
|