Development of Self-regenerating type Silk Vascular Graft for Artery and Vein

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05609
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 35020:Polymer materials-related
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Asakura Tetsuo 東京農工大学, 工学(系)研究科(研究院), 名誉教授 (30139208)
• Co-Investigator(Kenkyū-buntansha): 田中 綾 東京農工大学, (連合)農学研究科(研究院), 教授 (70334480)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 絹人工血管 / 高機能化絹 / 絹多孔質コーティング / ダブルラッセル編み / 動物移植評価実験 / 動脈・静脈用人工血管

Outline of Final Research Achievements

By combination of double-raschel knitting and several sponge coating, silk artificial vascular grafts with small diameter were prepared and implanted the grafts into artery and vein of rat. Especially, preparation of several coating was optimized by monitoring with sold-state NMR methods. After implantation of the silk artificial vascular grafts into artery and vein of rat, it was confirmed that some of blood vessels were regenerated. Thus, development of self-renewal silk artificial vascular grafts with small diameter for artery with high strength and vein with high elasticity has progressed.

Free Research Field

化学

Academic Significance and Societal Importance of the Research Achievements

高齢化社会や社会習慣病の増加を受け、需要が高まっているが未だ市販品のない小口径動脈用人工血管や市販品では閉塞しやすい静脈用人工血管について、問題点を克服した絹人工血管を開発した社会的意義は大きい。