2021 Fiscal Year Final Research Report
Regulation of immune system by mimetic peptides
| Project/Area Number |
19K05732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 37030:Chemical biology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ファージディスプレイ / 自己免疫疾患 / 自己抗体 / エピトープ |
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| Outline of Final Research Achievements |
Autoantibodies secreted from B cells in an autoimmune disease are sometimes correlated with the stage and are even associated with the onset of the disease. Such autoantibodies can be used as diagnostic markers. Immunoglobulin E is involved in the type I allergy. Using phage random peptide library, we have developed an efficient screening system for epitope mimetics against antibodies. In addition, we have established a system to obtain the epitope information directly from the autoantigen primary sequences by combining cDNA library screening and next-generation sequencing technologies.
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| Free Research Field |
糖鎖生物学、生体分子化学、創薬化学
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| Academic Significance and Societal Importance of the Research Achievements |
自己免疫疾患の一部やアレルギー疾患は体内に存在する抗体が抗原と結合することが引き金となって引き起こされる。本研究は、抗体が結合する抗原決定部位（エピトープと呼ばれる）を効率的に探索する、あるいはペプチド配列に置き換えることを目的に行った。本研究による成果は、将来的には上記疾患の診断マーカーに繋がる可能性があり、さらには液性免疫の制御法の開発に繋がる可能性があるものと考えられる。
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