2021 Fiscal Year Final Research Report
Development of a novel antibacterial agent aiming at reducing the emergence of new drug-resistant bacteria
| Project/Area Number |
19K05837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38040:Bioorganic chemistry-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
米山 裕 東北大学, 農学研究科, 教授 (10220774)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ドラッグデリバリー / monensin / S. aureus |
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| Outline of Final Research Achievements |
This research aimed to develop new antimicrobial agents with low risk of drug resistance by linking a peptide specific for Staphylococcus aureus with a biologically active natural product (monensin). So far, we have succeeded in synthesizing its derivative that is 8 times more potent in antibacterial activity than monensin itself. On the peptide side, through a search with a collaborator, we have found a peptide sequence with high adsorption ability against S. aureus. We believe that the coupling of the peptide with the monensin derivative will enable the creation of specific antimicrobial agents for S. aureus.
In addition, with the application of this concept in mind, we have also conducted synthetic studies of several natural products and succeeded in the total synthesis of natural products such as ktedonoketone and rossinones.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
薬剤耐性菌発生の主要因として抗生物質の過剰使用が挙げられる。抗生物質の使用対象でもっとも多いのはヒトではなく家畜であり，その用途は治療目的のみにとどまらず，健康な家畜の増体を目的とした飼料添加にまで及ぶ。これにより，畜産現場では抗生物質が過剰に使用され，薬剤耐性菌発生の温床になってい る。飼料添加剤としてもっとも汎用される抗生物質の一つがmonensinである。このものを特定の病原菌に特異的に輸送することができれば，他の菌に対する選択圧を下げることができるので，薬剤耐性菌発生リスクの低減が期待できる。本研究成果が薬剤耐性菌出現リスクの低い家畜用新規抗菌剤の開発の一助となることを期待したい。
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