2021 Fiscal Year Final Research Report
Recognition mechanism of dietary fiber-derived polysaccharides by intestinal immune cells.
| Project/Area Number |
19K05879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Gifu University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 食物繊維 / ペクチン / 炎症 / 病原性大腸菌 / 大腸 |
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| Outline of Final Research Achievements |
We found that pectin, a soluble dietary fiber, act on intestinal cells to protect against inflammatory diseases. This protective effects of pectin depend on its chemical structure (content of neutral sugar side chains and/or number and distribution of methyl ester groups). These results suggest the existence of a novel health-beneficial effect of dietary fiber that is independent of the intestinal microbiota.
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| Free Research Field |
食品免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
疫学研究により食物繊維の摂取と疾病の予防効果に相関があることが見出されてきたが，「どのような食物繊維（種類・質）をどのくらい（量）食べれば，どのような疾患を予防できるのか」を示す科学的根拠に乏しいのが現状である。本研究成果は，保健効果の発揮に寄与する食物繊維の質の一端を明らかにし，新たな機能性食品の創出や疾病時の食事介入に関する重要な基盤情報を提供するものである。
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