Elucidation of epigenome regulation mechanism by fatty acid binding protein

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05899
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: yamamoto yui 東北医科薬科大学, 医学部, 助教 (80635087)
• Co-Investigator(Kenkyū-buntansha): 大和田 祐二 東北大学, 医学系研究科, 教授 (20292211)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: FABP / FABP3 / 多価不飽和脂肪酸 / 抑制性介在神経 / 抑制性介在ニューロン / パルブアルブミン

Outline of Final Research Achievements

It has been suggested that lipid homeostasis changes in developmental brain are associated with abnormal neuroplasticity after growth. In this study, we examined the relationship between abnormal lipid metabolism and changes in neuroplasticity in inhibitory interneurons and astrocytes that are particularly vulnerable to environmental changes during development.
We mainly revealed that fatty acid binding protein (FABP) in the cortical inhibitory interneurons is involved in the expression of cognitive and emotional behaviors through regulation of neurite outgrowth, and that FABP in astrocyte is important in the control of lipid metabolism and it is also involved in the neuronal plasticity control through epigenetic regulation of genetic information.
These results are expected to contribute to the research and development of mental illness and health medicine.

Free Research Field

解剖学

Academic Significance and Societal Importance of the Research Achievements

本研究により、発達期脳内脂質環境の変化が、新たなタンパク質相互作用を生み出し、エピゲノム修飾に影響を及ぼすことが示唆される。今後さらに詳細な解析を加えることで、FABPが関与する発達障害の病態解明、治療創薬の開発に大きく貢献できると考える。