Regulation of Tropomyosin receptor kinase B (TrkB) by ethanol

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K05904
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Gihu University of Medical Science
• Principal Investigator: Matsui Nobuaki 岐阜医療科学大学, 薬学部, 准教授 (60309698)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: エタノール / TrkB / GluA1 / p70S6K / GSK-3β / 抗うつ作用

Outline of Final Research Achievements

Ethanol increased phosphorylation of the brain-derived neurotrophic factor (BDNF) receptor TrkB and its downstream signaling pathways GSK-3beta and p70S6K in the prefrontal cortex and hippocampus of mice. Ethanol also increased phosphorylation of the AMPA receptor subunit GluA1 and showed rapid antidepressant-like effect in mice. Ethanol did not exert neurotrophic factor-like effects in cultured neurons, suggesting that ethanol activates TrkB by some indirect mechanism.

Free Research Field

薬理学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、エタノールが間接的に脳内で神経栄養因子受容体の作用を増強することが示された。これは、過度の飲酒はうつ病を悪化させるが適度な飲酒はうつ病の発症リスクを低下させるという報告や、過量でない飲酒がアルツハイマー病のリスクを低下させるという報告など酒類の健康増進効果の科学的エビデンスとなる可能性がある。