The mechanism elucidation of anti-obesity effect about tea beverage containing soluble hesperidin

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K05921
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Fukuoka Institute of Technology
• Principal Investigator: Hase Shizuka 福岡工業大学, 工学部, 准教授 (10448821)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 未利用資源の有効活用 / 緑茶三番茶葉 / 未熟温州ミカン / ヘスペリジンの可溶化 / 紅茶 / 肥満・脂肪肝・脂質異常症の改善 / ラット / マウス

Outline of Final Research Achievements

We have manufactured and developed novel tea leaves made by mixing and fermenting of unripe, inedible, and wasted Satsuma mandarin and poor quality third cropped green tea leaves. The hot water extract of the mixing and fermenting tea leaves (mandarin mixed tea beverage, MTB) is a new type of black tea that makes effective use of unused resources and improves the insolubility of hesperidin derived from unripe mandarin oranges by coexisting with catechins and their polymers.
In this study, we investigated the effect of administration of MTB on obesity and lipid metabolism in mice and rats. Obvious anti-obesity effect was observed in C57BL/6J mice and SD rats drinking MTB. Hepatic lipid lowering activity was also suggested. These effects were exerted though, in part, the improvement of insulin and leptin sensitivity, suppression of lipase activity, and expenditure of carbohydrate as energy.

Free Research Field

食品栄養学

Academic Significance and Societal Importance of the Research Achievements

規格外の野菜・果実などは、食用と同等もしくはそれ以上に栄養豊富であるにも関わらずその多くが産業廃棄物として処理されている。本研究では、未利用資源である摘果（未熟）ミカンと緑茶三番茶葉を有効活用し、かつ健康効果を見出した点において、産業廃棄物の削減ならびに肥満に関わる諸疾患の予防による国の医療費負担軽減につながる。さらに、地元特産品を用いた加工食品の製造開発により新事業が創出され、地域活性化につながる。これらの社会的意義に加え、学術的意義としては、これまで不溶性のヘスペリジンは人工的な糖転移により可溶化していた所、本研究では化学反応によらず天然成分の共存により可溶化させた点が意義深い。