2021 Fiscal Year Final Research Report
Research on exposure estimation of inorganic nanoparticles contained in / adhered to food
Project/Area Number |
19K05924
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 38050:Food sciences-related
|
Research Institution | National Institute of Health Sciences |
Principal Investigator |
Yoshinari Suzuki 国立医薬品食品衛生研究所, 食品部, 室長 (40469987)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Keywords | ナノ粒子 / ICP-MS / 食事性曝露 |
Outline of Final Research Achievements |
A preparation method for extracting silver nanoparticles (Ag-NPs) from solid samples such as food products for sp-ICP-MS was investigated, and an enzyme-based extraction method was found to be appropriate. When this method was applied to oyster samples, Ag-NPs with an average particle size of 24-32 nm and a maximum particle size of 63-361 nm were detected. Using the composite samples, we estimated the average Japanese exposure to Ag-NPs to be 1.8 μg/person/day, or 15 billion particles/person/day. The health risk from dietary exposure to Ag-NPs was estimated to be small.
|
Free Research Field |
食品衛生学
|
Academic Significance and Societal Importance of the Research Achievements |
ナノマテリアル (NMs) の工業的利用の増加に伴い、食品を介したNMsのヒトへの曝露による安全性への影響が懸念されている。また、新型コロナの蔓延に伴い、抗菌材として使用されている銀ナノ粒子( Ag-NP) によるリスクに関心が高まっている。本研究は、このようなAg-NPに関して、平均的な食事性曝露量を評価したものである。推定されたAg-NPの耐容摂取量と食事性曝露量を比較し、Ag-NPの健康リスクが低いことを明らかとした。
|