Analysis of the molecular basis for stem cell differentiation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K05943
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38060:Applied molecular and cellular biology-related
• Research Institution: Nagoya University (2022); The University of Tokyo (2019-2020)
• Principal Investigator: Shimotohno Akie 名古屋大学, トランスフォーマティブ生命分子研究所, 特任講師 (70647544)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 幹細胞 / 発生・分化 / 植物ホルモン / 低分子タンパク質

Outline of Final Research Achievements

The aim of this study was to identify a new component of regulatory factors regulating stem cell differentiation. Unexpectively, due to the COVID-19 outbreak, our activities were unexpectedly limited. We nonetheless managed to complete the MS analysis and identify several novel regulatory factors that interact with key transcription factor components. In addition, we successfully established a tool for live cell imaging of protein dynamics in plants, thus mainly fulfilling our objectives.

Free Research Field

植物分子生物学

Academic Significance and Societal Importance of the Research Achievements

本研究は、植物の幹細胞化に必要不可欠な転写因子群が、生体内でどのような制御を受けているのかを示すことに成功した。今後は、これらの制御因子機能の発揮に至る分子機序を詳らかにすることによって、植物がもつ永続的な幹細胞能力の謎の解明につなげることが期待できる。