Mechanisms and biomarkers of epithelial/endothelial-mesenchymal transition in glomerular disease of dogs and cats

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K06385
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42020:Veterinary medical science-related
• Research Institution: Kagoshima University
• Principal Investigator: Yabuki Akira 鹿児島大学, 農水産獣医学域獣医学系, 教授 (10315400)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 糸球体疾患 / 犬 / 上皮間葉転換 / 筋線維芽細胞

Outline of Final Research Achievements

In this study, we investigated the epithelial-mesenchymal transition in glomerular disease of dogs and cats. Incident of the glomerular disease was found in dogs. Immunohistochemical analysis was performed in the kidneys of dogs that were diagnosed with glomerular disease by renal biopsy. The results showed that epithelial mesenchymal transition occurred in most dogs but it did not depend on the type of the glomerular disease. It was considered that myofibroblasts were derived not only from epithelial mesenchymal transition but also from other mechanisms.

Free Research Field

獣医腎泌尿器病学

Academic Significance and Societal Importance of the Research Achievements

糸球体疾患は難治性かつ進行性の腎疾患である。本疾患は人だけでなく犬や猫にも発生し、特に犬で多く発生する。犬や猫では、糸球体疾患の根本的な治療は難しく、本疾患に罹患した動物の飼い主の心的および経済的負担は非常に大きい。本疾患の予防および治療に有効的な方法を見出すには、その病理学的な進行機序を明らかにする必要がある。本研究の成果は、その機序の一つである上皮間葉転換について明らかにしたものとして学術的および社会的な意義を有している。