2022 Fiscal Year Final Research Report
Isolation and characterization of a herpes-like virus circulating in wild cranes
| Project/Area Number |
19K06424
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 42020:Veterinary medical science-related
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2023-03-31
|
| Keywords | ヘルペスウイルス / ツル科 / 野生鳥類 / 病原性 |
|---|
| Outline of Final Research Achievements |
In this study, herpes-like viruses were isolated from hooded cranes that migrated into the Izumi plain in Kagoshima prefecture, Japan. Whole genome analysis revealed that the genome length of the virus is approximately 159 kbp and 83 open reading frames are contained in the genome. Phylogenetic analysis demonstrated that the virus is genetically closely related to the genus Mardivirus of the subfamily alphaherpesviridae. In pathogenicity test using embryonated egg, the virus caused fatal infection in chicken embryos and duck embryos, suggested that those poultry species are susceptible to the virus infection. Characteristics of the virus from cranes will be useful information for infectious disease control of the herpesvirus derived from cranes.
|
| Free Research Field |
獣医学
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究課題においてツルに病原性を示すヘルペスウイルスの遺伝学的性状および生物学的性状を明らかにした。得られたゲノム配列は、ヘルペスウイルスの多様性と進化を正確に知るうえで貴重な情報になり、さらに、本ウイルス感染症における遺伝子診断技術開発の基礎情報としても有用と考えられる。ツル科鳥類の多くの種は、国際自然保護連合（IUCN）により絶滅の危機に瀕していると評価されていることから、本研究成果はツルの感染症対策を通じた保護活動に将来役立てられる事が期待される。
|
