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2021 Fiscal Year Final Research Report

The role of imprinted genes in metabolic regulation and their evolutionary significance.

Research Project

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Project/Area Number 19K06607
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 43050:Genome biology-related
Research InstitutionGunma University

Principal Investigator

Morita Sumiyo  群馬大学, 生体調節研究所, 助教 (40589264)

Co-Investigator(Kenkyū-buntansha) 堀居 拓郎  群馬大学, 生体調節研究所, 准教授 (00361387)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywordsゲノムインプリンティング / 白色脂肪 / 褐色脂肪
Outline of Final Research Achievements

In mammals, paternally and maternally derived genomes are not functionally equivalent. This is due to the presence of imprinted genes that are expressed in a paternal- and maternal-derived allele-specific manner. In this study, we analysed the function of imprinted genes in obesity-associated brown and beige adipocytes. Furthermore, conditioned knockout mice of one of the imprinted genes, Meg3, were generated and examined for their involvement in obesity or emaciation. In this way, the role of imprinted genes in metabolic regulation (heat production) in brown and beige adipocytes was clarified and the biological and evolutionary significance of genomic imprinting was discussed.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

多くの哺乳類でみられる褐色脂肪細胞やベージュ脂肪細胞は全身のエネルギー代謝を制御していることが明らかとなってきた。これらの脂肪細胞は活発に熱を産生しエネルギーを消費することから、肥満や生活習慣病の治療標的として極めて注目されている。本研究ではこれらの脂肪細胞におけるインプリント遺伝子の役割を解析することでインプリント遺伝子の生物学的意義を解明するだけでなく、新たに熱産生機能に関与することが明らかとなったインプリント遺伝子は創薬の標的となる可能性をもち、肥満や生活習慣病の新たな治療戦略として活用できるのではないかと考える。

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Published: 2023-01-30  

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