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2021 Fiscal Year Final Research Report

A novel oxygen-dependent plant two-component regulatory system - from an evolutionary perspective.

Research Project

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Project/Area Number 19K06779
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45010:Genetics-related
Research InstitutionNagoya University

Principal Investigator

Aoki Setsuyuki  名古屋大学, 情報学研究科, 准教授 (30283469)

Project Period (FY) 2019-04-01 – 2022-03-31
Keywords多段階リン酸リレー / 概日時計 / 低酸素応答 / ヒスチジンキナーゼ / PASドメイン / ヒメツリガネゴケ / 時計タンパク質 / 糖代謝
Outline of Final Research Achievements

I have studied two PAS-histidine kinases (PHK1/2) and their downstream multi-step phosphorelay pathway in the moss Physcomitrium patens, and obtained the following results: (i)PHK1/2 interact with intermediate factors HPt1/2 in the nucleus, and upon red light irradiation, those distributions expanded to the nucleocytoplasm; (ii)HPt1/2 interact with "circadian clock" proteins PRR1~3 in the nucleus; (iii)PHK1/2 is diurnally regulated and they are localized and interact with HPt1/2 in the nucleus at night and in the nucleocytoplasm during the day; (iv) PHK1/2 regulate transcription of downstream genes, e.g., those related to the circadian clock and sugar metabolism. Thus, we have unveiled a unique and novel eukaryotic MSP pathway in this study.

Free Research Field

植物分子生理学

Academic Significance and Societal Importance of the Research Achievements

PHK1とPHK2は低酸素環境化でコケ植物の生育を制御する因子です。この研究では、PHK1/PHK2に始まる細胞内の情報伝達の仕組みを研究しました。その結果、PHK1/PHK2は、中継因子を介して、体内時計の部品であるタンパク質の一部に情報を伝達し、さらに、体内時計の部品タンパク質をコードする遺伝子群や、また糖の代謝に関係する遺伝子群の転写レベルを制御することを明らかにしました。これにより、植物が低酸素環境や日内変動する環境に適応する仕組みの理解がすすみ、将来的には冠水条件や高地の低酸素条件でも効果的に生育する農作物の開発等につながると期待できます。

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Published: 2023-01-30  

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