2021 Fiscal Year Final Research Report
Visual information shared between visual cortex and superior colliculus and their mutual regulation mechanisms
| Project/Area Number |
19K06940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46030:Function of nervous system-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 上丘 / 視覚 / 方向選択性 / 方位選択性 / ２光子顕微鏡 / in vivo イメージング |
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| Outline of Final Research Achievements |
The superior colliculus is a key structure for subcortical visual processing, multimodal sensory integration, and sensory-motor transformation, in the midbrain. In this project, I focused on the loop-like circuits between the superior colliculus and the visual cortex. I developed the method for visualizing and manipulating pathway-specific neural circuit dynamics between the superior colliculus and the visual cortex.
I also found that the isofluorane anesthesia changed the spatial properties of the neuronal population responses. This suggested that the functional organization in the visual layer of the superior colliculus might be altered in various states by the local circuit mechanisms or top-down input from the cerebral cortex.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
上丘は，進化的に古くから感覚情報の統合や感覚－運動変換を司る脳領域として古くから発達している．哺乳類が獲得した大脳皮質を発達させたことで高次の脳機能に獲得したが，上丘の意識にのぼる知覚への関与については不明な点が多い．本研究で上丘と視覚野が作る神経回路活動を記録・操作すること可能になり，新旧の情報統合領域の関係，違いを比較するで，上丘の認知機能への影響を評価する系が確立できた．
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