2021 Fiscal Year Final Research Report
Social memory representation in the ventral hippocampus
Project/Area Number |
19K06951
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 46030:Function of nervous system-related
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Research Institution | The University of Tokyo |
Principal Investigator |
Tao Kentaro 東京大学, 定量生命科学研究所, 助教 (10708481)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 腹側海馬 / 社会性記憶 |
Outline of Final Research Achievements |
we found that social memory neurons in the CA1 area of the ventral hippocampus, characterized by enhanced activity in response to memorized individuals, were preferentially reactivated during sharp-wave ripples (SPW-Rs). Spike sequences of these social replays reflected the temporal orders of neuronal activities within theta cycles during social experiences. In ASD model Shank3 knockout mice, the proportion of social memory neurons was reduced, and neuronal ensemble spike sequences during SPW-Rs were disrupted, which correlated with impaired discriminatory social behavior. These results suggest that SPW-R-mediated sequential reactivation of neuronal ensembles is a canonical mechanism for coordinating hippocampus-dependent social memories and its disruption underlie the pathophysiology of social memory defects associated with ASD.
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Free Research Field |
神経生理学
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Academic Significance and Societal Importance of the Research Achievements |
本研究成果により腹側海馬における社会性情報の符号化原理およびその調節機構が記述されたことで、我々がどのように他者を記憶・認識しているのかを解明するうえで重要な知見が得られるとともに、自閉症スペクトラム障害など社会性記憶の低下が中核症状のひとつである精神疾患の病態生理について多角的な理解が進むことが期待される。
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