Development of reusable rhodium catalyst and its sequential reactions, and application for new drug discovery

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K06971
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: University of Toyama
• Principal Investigator: Yakura Takayuki 富山大学, 学術研究部薬学・和漢系, 教授 (70220126)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ロジウム触媒 / 再使用 / 反応重奏化 / 創薬 / イリド / C-H挿入 / C-Hアミノ化

Outline of Final Research Achievements

Metal-catalyzed carbenoid reaction of diazo compounds is one of the best reactions for beginners due to its easy treatment. And it is one of the most environmentally benign reactions because by-product is only nitrogen gas and the used metal can be easily recovered. For further enhancement of metal-catalyzed carbenoid reaction, development of reusable rhodium catalyst and its sequential reactions were investigated. Moreover, application for a few natural product synthesis was also tried.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

複数の触媒が重奏的に関与する連続反応系を創製できれば極めて効率の高い有機合成反応が可能となる。特に，活性化されていないC-H 結合を官能基化できれば，化合物合成の簡素化をもたらす。また，ナノ粒子触媒は回収・再使用容易な触媒としてその利用が始まったところである。本研究はもっとも注目されている反応の開発を新触媒創製手法を用いておこない，創薬課題へと展開するものであり，本研究はこれらの分野へ貢献できる。