2022 Fiscal Year Final Research Report
Development of a novel anticancer agent with MRI contrast effect and induction of oxidative stress
| Project/Area Number |
19K07037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | ビタミンK / ニトロキシラジカル / 抗がん剤 |
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| Outline of Final Research Achievements |
While vitamin K is one of the nutrients necessary for living organisms, it is toxic to various tumor cells by producing superoxide radicals and causing oxidative stress in cells. Therefore, vitamin K may function as a new anti-cancer agent when combined with compounds that enhance its toxicity. In this study, we demonstrated that low molecular weight nitroxyl radicals with MRI contrast and SOD-like activity potentiate the cytotoxicity of vitamin K3, indicating the possibility of developing new anticancer agents by combining these compounds.
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| Free Research Field |
生物物理
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| Academic Significance and Societal Importance of the Research Achievements |
ビタミンKの腫瘍細胞に対する毒性は古くから知られており、これまでに様々なビタミンK類縁体が合成されている。しかしながら、癌治療の補助剤として使われる場合があるのみで、主要な抗がん剤として利用されていない。本研究はビタミンKの腫瘍細胞に対する毒性を増強させる化合物を見いだしたものであり、ナノ粒子化によるビタミンKの新たな抗がん剤としての可能性を示すことができた。
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