Identification of target molecules of novel anticancer drug candidates and elucidation of their mechanisms of action

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: Kumamoto University
• Principal Investigator: Tsuchiya Soken 熊本大学, 大学院生命科学研究部(薬), 講師 (80423002)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: がん

Outline of Final Research Achievements

We succeeded in synthesizing a new anti-cancer drug candidate compound discovered by screening of small molecule compounds, and found that the newly synthesized compound has equivalent anti-cancer activity and also has activities inducing cancer cell death in several types of cancer cells. In addition, we modified the compound for the aim of identification of the target molecule, and found that the newly modified compound retained theequivalent anti-cancer activity as the compound without the linker modification in several types of cancer cells.

Free Research Field

生化学

Academic Significance and Societal Importance of the Research Achievements

国内において、２人に１人ががんに罹患し、３人に１人ががんによって亡くなっており、患者やその家族にとってはもちろん、国家の医療財政上においても、がんは極めて深刻な疾患である。その治療に全身性作用を有する抗がん剤の位置づけは極めて重要であるが、食道がんなど、多くの種類のがんにおいて様々な観点から新たな抗がん剤の開発が強く望まれている。以上の背景の下、新たな抗がん剤の開発を目指し、抗がん活性を有する新規骨格化合物の新規合成、修飾に成功した本研究成果は学術的意義、社会的意義を有する。