Regulation of cell division by the receptor-type tyrosine kinase

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07055
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Nakayama Yuji 京都薬科大学, 薬学部, 教授 (10280918)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 細胞分裂 / 受容体型チロシンキナーゼ / EphA2 / IGF1R / ALK / v-Src

Outline of Final Research Achievements

Cell division is a process that divides replicated DNA into two daughter cells and is mainly regulated by the Ser/The kinases CDK1, Aurora kinases, and PLK1. In this study, roles of the receptor-type tyrosine kinases in cell division were explored, since inhibition of these proteins by inhibitors and/or siRNA caused failure in cell division. Interestingly, combination treatment of IGF1R inhibitor and Aurora B inhibitor caused severe suppression of cell proliferation via causing abnormal cell division. Furthermore, abrogation of tyrosine signaling decreased the sensitivity against the microtubule-targeting anticancer drugs.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

細胞分裂制御関連タンパク質の機能異常は染色体不安定性を介して細胞のがん化に関与するため，新規制御機構の解明は，新たな細胞がん化機構の発見につながる。また，細胞分裂制御に関わるタンパク質は，抗がん剤を開発するための標的分子となる可能性がある。