2022 Fiscal Year Final Research Report
Effects of oxidized lipoproteins on neutrophil extracellular trap formation followed by vascular inflammation
| Project/Area Number |
19K07069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 好中球細胞外トラップ / 血管内皮細胞 / 酸化LDL / HDL / 動脈硬化症 |
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| Outline of Final Research Achievements |
We found that endocytosis and endothelial-mesenchymal transition are involved in the morphological changes of vascular endothelial cells induced by NETs and LDL or copper-oxidized LDL. In vivo oxidized LDL promoted NET formation of HL-60-derived neutrophils more mildly than copper-oxidized LDL. Enhanced NET formation induced by copper-oxidized LDL and its components, oxidized phospholipids and lysoPC, was inhibited by the coexistence of HDL. Oxidation of HDL not only abolished these inhibitory effects but also promoted NETs formation similarly to copper-oxidized LDL.
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| Free Research Field |
脂質生化学
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| Academic Significance and Societal Importance of the Research Achievements |
循環器系疾患の危険因子である酸化LDLの生理的役割について、これまでに知られているマクロファージの泡沫化を介した血管壁での脂質蓄積促進作用に加えて、好中球のNETs形成の促進とともに血管内皮の炎症惹起と形質変化を促す新たな機序が見出される可能性が示唆された。
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