2021 Fiscal Year Final Research Report
The effects of endogenous PUFA restriction on biological functions
Project/Area Number |
19K07087
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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Research Institution | Showa University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 多価不飽和脂肪酸 / 長鎖アシルCoA合成酵素4 / PUFA / ACSL4 / リポ多糖 / フェロトーシス |
Outline of Final Research Achievements |
The aim of this study was to identify the biological functions of polyunsaturated acid (PUFA) using Acsl4 knockout mice and human tubular epithelial cells. This study showed that ACSL4 deficiency enhanced the inflammatory responses induced by lipopolysaccharide, which may involve enhanced production of bioactive lipid mediator(s). It also showed that the ferroptosis/ferroptosis-like cell death observed in human renal epithelial HK-2 cells was mediated by a different pathway from that previously reported.
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Free Research Field |
衛生薬学、脂質生化学、生化学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、多価不飽脂肪酸の生体や細胞内での利用が、すべての細胞で共通の機構で行われるのではなく組織や細胞の種類で異なること、また、PUFAを介する細胞死の機構も細胞間で異なることを明らかとした。
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