Antipsychotic drug repositioning for chemotherapy-induced nausea and vomiting and mechanism elucidation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07230
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Keio University
• Principal Investigator: KAWAZOE Hitoshi 慶應義塾大学, 薬学部(芝共立), 准教授 (60527563)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 悪心・嘔吐 / 抗精神病薬 / ドラッグ・リポジショニング / パイカ行動 / カオリン

Outline of Final Research Achievements

In clinical practice, chemotherapy-induced nausea and vomiting have to be well controlled because they greatly reduce the patients' quality of life. The development of more effective antiemetic drugs is expected to improve the continuation rate of chemotherapy treatment, treatment efficacy, and patients' quality of life. In this study, behavioral pharmacology experiments were conducted in mice and rats, suggesting that drugs other than olanzapine, which are used in the field of psychiatric disorders, could be used as antiemetics for chemotherapy.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

本研究により、臨床で問題となる抗がん剤に伴う悪心・嘔吐に対する新たなより制吐効果が高い薬の開発は抗がん剤治療継続率、治療効果および患者の生活の質の向上に繋がる。抗精神病薬は精神疾患領域で長期に渡る使用実績があり、医療経済の観点からも有意義であり、安全で有効な制吐薬として社会的意義が大きいと考える。