2021 Fiscal Year Final Research Report
Investigation of pathogenic mechanism of frontotemporal lobe degeneration based on novel hypothesis
| Project/Area Number |
19K07329
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48030:Pharmacology-related
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 神経変性疾患 / 神経細胞死 |
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| Outline of Final Research Achievements |
Neurodegenerative diseases, including Alzheimer's disease and frontotemporal lobar degeneration, are caused by neuronal cell death, resulting in impairment of cognitive or motor functions. Although many neurodegenerative disease-causative genes have been identified, therapeutic agents have yet to be established.
Many of the proteins encoded by neurodegenerative disease-causative factors are ubiquitously expressed and widely distributed in the brain. But brain regions undergoing degeneration are limited by each neurodegenerative disease. Therefore, it is possible that there is a regulatory mechanism that determines the degenerative regions.
In this study, we generated novel mouse models of neurodegenerative diseases and investigated the mechanisms involved in the regulation of neurodegenerative regions.
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| Free Research Field |
薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、新たな神経変性疾患モデルマウスを作製し、このマウスが神経変性領域の制御メカニズムの解明に向けた研究ツールとして有効であること明らかにした。このモデルマウスを用いた解析は、神経変性疾患の発症メカニズムの解明のみならず、根本的治療法および治療薬の確立への基盤になるものと考えられる。
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