2021 Fiscal Year Final Research Report
Investigation of immune regulation by CD8aa T cells differentiated from CD4 T cells.
| Project/Area Number |
19K07347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 48040:Medical biochemistry-related
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| Research Institution | University of Fukui |
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Principal Investigator |
Nambu Yukiko 福井大学, 学術研究院医学系部門, 准教授 (70580380)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | CD8ααT細胞 / 制御性T細胞 / 再分化 |
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| Outline of Final Research Achievements |
CD8aa T cells differentiated from CD4 T cells play an important role in converging prolonged inflammation. The mechanism of immune regulation by CD8aa T cells still be unknown. In this study, I tried to monitor the appearance of CD4-derived CD8aa T cells during the normal course of immune reaction, but failed. To analyze CD4-derived CD8aa T cells I made mice having fluorescent protein only within CD4 T cells, however other cells were also labeled with fluorescent protein in these mice. As I overcome this trouble, I considered superior strategy and prepared the new construction for generating another mouse. After validating it in vitro, I will make another mouse for suitable for specific labeling of CD4 T cells.
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| Free Research Field |
分子生物学・免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
研究代表者が発見した新規CD8αα T細胞は、免疫反応の進行に伴ってCD4 T細胞から再分化して生じる。この細胞を持たないマウスでは自己免疫疾患様の病態を示すことから、CD4+制御性T細胞とは違ったメカニズムで免疫を抑制する、新しい制御性T細胞であることが示唆された。この細胞の分化機構や、免疫反応の制御機構が判明すれば、今までない免疫反応制御の分子的および知的基盤を提供することが可能である。本研究では、不完全とは言え、CD4 T細胞から再分化するCD8αα T細胞の標識に成功しており、このマウスを解析することによって、さらなる知見を得ることが期待される。
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