2022 Fiscal Year Final Research Report
Functional analysis of death receptor 6 in anti-tumor immunity
Project/Area Number |
19K07360
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 48040:Medical biochemistry-related
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Research Institution | Kitasato University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
北村 浩 酪農学園大学, 獣医学群, 教授 (80312403)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | TNFRSF21 / 腫瘍 / マクロファージ |
Outline of Final Research Achievements |
Death receptor 6 (DR6, TNFRSF21) is a member of tumor necrosis factor receptor superfamily. It has been reported that DR6 is involved in the pathogenesis of various immune disease mouse models. Although DR6 expression has been reported in various cancer tissue samples, the functional role of DR6 in immune responses to tumors remains unclear. To elucidate the role of DR6 in tumor immunity, we generated DR6-deficient BALB/c mice and analyzed the functional role of DR6 in tumor immune responses using a CT26 cell-bearing mouse model. We found that DR6 deficiency affects the infiltration of immunocompetent cells into the transplanted tumor tissue, but should not significantly affect tumor mass formation.
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Free Research Field |
分子免疫学
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Academic Significance and Societal Importance of the Research Achievements |
DR6はがん患者組織や種々の腫瘍由来培養細胞における発現亢進が報告されており、また、腫瘍マーカーとしての可能性が報告されるなど、DR6と腫瘍形成への関与が示唆されるが、その機能的役割については不明な点が多い。本研究では、DR6欠損BALB/cマウスを作成し、マウス腫瘍細胞同種移植モデルを用いて、腫瘍に対する宿主側免疫応答におけるDR6の機能について解析を行った。本研究では宿主側免疫細胞の腫瘍浸潤に対してDR6が機能的に関与しうることが明らかとなった。今後はDR6を発現する免疫細胞が関与する他の免疫疾患におけるDR6の機能的役割を解析することで、DR6が新たな免疫療法標的分子となるか検討したい。
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