2022 Fiscal Year Final Research Report

Analysis of the contribution of satellite cells to sarcopenia

Research Project

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Project/Area Number	19K07396
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 49010:Pathological biochemistry-related
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Matsuzaki Kyoko (有本京子) 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (90568932)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	サテライト細胞 / サルコペニア / 老化
Outline of Final Research Achievements	In this study, I focused on age-related changes in skeletal muscle tissue stem cells (satellite cells) as a new target for the treatment of sarcopenia. By isolating satellite cells from HGPS mice, a mouse model that mimics human progeria, it was clarified that satellite cells lose stemness and proliferative ability with aging. Furthermore, I found that the decrease of Myc signal is one of the causes of diminished proliferative capacity. In addition, considering that it is important to restore the proliferative ability of satellite cells as a method of preventing and treating sarcopenia, I screened a library of low-molecular-weight compounds and identified several candidate compounds that promote the proliferative ability of satellite cells.
Free Research Field	細胞生物学
Academic Significance and Societal Importance of the Research Achievements	サルコペニアは高齢者が要介護になる主要な背景病態の一つであり、少子高齢化が進み、労働人口が減少する日本にとってサルコペニア対策は重要な政策課題である。サルコペニアを予防、治療するためには病態機構の解析が必須であるが、その詳細には不明な点が多く効果的な薬剤は未だ開発されていない。本研究では、サテライト細胞が加齢に伴い質的に変化することを見出し、サテライト細胞がサルコペニアの発症に強く関わっていることを示唆した。したがって、サテライト細胞がサルコペニア治療の有望なターゲットになると期待され、その社会的意義は大きい。