Elucidating of the effect of mitochondrial respiratory supercomplex-regulated metabolism and reactive oxygen species on disease/lifespan.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49010:Pathological biochemistry-related
• Research Institution: Josai University
• Principal Investigator: Shiba Sachiko 城西大学, 薬学部, 助教 (70633824)
• Co-Investigator(Kenkyū-buntansha): 池田 和博 埼玉医科大学, 医学部, 准教授 (30343461)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ミトコンドリア / 遺伝子改変マウス / 糖代謝 / 脂質代謝

Outline of Final Research Achievements

In the genetically modified mice with alteration of mitochondrial respiratory supercomplex-promoting factor, COX7RP, several inflammation-related markers were affected. In a rat model of nonalcoholic steatohepatitis (NASH) which is closely related to lifestyle-related diseases and exhibits morphological and functional alteration of mitochondria, nitrite administration improved the pathological phenotypes through suppression of reactive oxygen species (ROS)-generating signals. In addition, eicosapentaenoic acid (EPA) enhanced ROS production and reduced the viability in prostate cancer cells. These results implicate a close relationship between mitochondrial metabolism, ROS generation, and dietary factors in lifestyle-related diseases and aging, which may be useful for new preventive and therapeutic medicine.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

ミトコンドリアはエネルギー産生の主要な役割を担っている。一方で、酸化ストレスの原因となる活性酸素の主要な発生源にもなっており、加齢・老化や生活習慣病において重要な役割を担うと考えられている。本研究によって、生活習慣病、老化などにおけるミトコンドリア代謝、ROS 制御と食餌性因子の密接な関連が示され、加齢・老化や生活習慣病等の病因解明と新たな予防・治療法への応用が期待され、社会的にもこれら疾患の改善や健康維持などに資すると期待できる。