Clinicopathological significance of T-UCR and molecular classification in gastrointestinal cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Hiroshima University
• Principal Investigator: Sentani Kazuhiro 広島大学, 医系科学研究科(医), 講師 (30508164)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: T-UCR

Outline of Final Research Achievements

This study includes the clinicopathological and biological analysis of T-UCR in urothelial carcinoma. We clarified that increased expression of Uc.63+ enhanced proliferation activity, and its decrease lead to cisplatin sensitivity. And we analyzed the relationship between intratumoral heterogeneity and molecular classification in gastric cancer (GC). GC cases with more histological numbers or mixed types in invasive areas showed significantly higher T grade and staging, poorer prognosis and characteristically expressed cancer stem cell-related molecules (CD44, CD133 or ALDH1) and receptor tyrosine kinase molecules (HER2, EGFR or c-MET) as well as chromosomal instability subtype of GC. In addition, we demonstrated the clinicopathological significance of claspin and intelectin-1 in gastrointestinal and urological organs.

Free Research Field

人体病理

Academic Significance and Societal Importance of the Research Achievements

本研究では、消化管癌および泌尿器系癌のT-UCRs発現解析に基づいて得られるデータを基盤として、対象とするT-UCRsの発現を制御するmicroRNAや標的とする分子に焦点を当てて解析を行った。得られたデータにより抗がん剤抵抗性を促進する機構など予後不良あるいは治療抵抗性を示す癌のメカニズムの一部を明らかにした。一方で癌の治療抵抗性の原因の一つである腫瘍内不均一性と分子分類との関係を調べるとともに、複数の癌関連分子の臨床病理学的特徴を明らかにした。これらの成果は今後さらなる診断、治療への応用が期待される。