Gene expression analyses by nCounter system for EBV associated lymphoproliferative disorders.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Kurume University
• Principal Investigator: Miyoshi Hiroaki 久留米大学, 医学部, 准教授 (30647780)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: EBウイルス / mRNA / 発現解析

Outline of Final Research Achievements

Epstein-Barr virus (EBV) is reported to play significant role in tumorigenesis of some kinds of lymphoproliferative disorders (LPDs). EBV-associated molecules and tumor microenvironment-associated molecules including tumor immunity are considered to be important in progression of those LPDs.
In this study, gene expression analyses showed that MTX associated LPDs had higher expression of specific genomic group, which might contribute to disease progression. EBV-T/NK LPD had higher expression of specific immune cells in comparison to EBV positive T-cell lymphoma and extranodal NK/T cell lymphoma.

Free Research Field

血液病理学

Academic Significance and Societal Importance of the Research Achievements

リンパ増殖性疾患は希少疾患であり、病態解明が進みにくい現状がある。しかしながら、今回の研究により、メトトレキサート関連リンパ増殖性疾患およびEBV関連T/NK細胞リンパ増殖性疾患では、他の疾患と比較した場合に腫瘍周囲の免疫環境に違いがあることが示された。
今回の結果をもとにさらに病態解明が進むことで、EBVの関与しているリンパ増殖性疾患に対する適切な治療選択や患者さんの予後の改善が期待される。