2021 Fiscal Year Final Research Report
Analysis of the regulatory mechanism of macrophages involved in homeostasis by the transcription factor MafB
| Project/Area Number |
19K07499
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | MAFB / マクロファージ / 恒常性 |
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| Outline of Final Research Achievements |
Monocytes-macrophages are necessary for tissue repair and maintenance of immune homeostasis, and when these functions are impaired by chronic disorders, macrophages themselves become a pathological factor. In atherosclerosis, myocardial infarction, and tumors, the tissue repair function of macrophages may inversely aggravate the disease state. It has recently become clear that most of the monocytes infiltrating these lesions originate from the spleen, and this mechanism is attracting attention as a new therapeutic target. In this research project, we will demonstrate that the transcription factor MafB is required for the production of monocytes-macrophages in the spleen, and conduct research with the aim of searching for new therapeutic targets for various macrophage-associated pathologies.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は脾臓から病変部や組織に浸潤するマクロファージ数を決定するメカニズムが脾臓マクロファージにあることを明らかにするという点で独自性、創造性が高いと考えている。このメカニズムが明らかとなり、転写因子MAFBの発現をコントロールすることによりマクロファージ数を制御することができれば、腫瘍だけではなく、心筋梗塞、急性腎障害などマクロファージが関わる疾患に対して効果を持つ、これまでにない薬剤の開発に役立つものと思われる
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