A gene that controls the pathogenicity of bacteria

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K07563
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49050:Bacteriology-related
• Research Institution: Jikei University School of Medicine
• Principal Investigator: IWASE TADAYUKI 東京慈恵会医科大学, 医学部, 教授 (80385294)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 病原性 / 生態 / 進化

Outline of Final Research Achievements

In this study, we found that a gene in the genome of enterohemorrhagic Escherichia coli, the function of which has not been clarified, is involved in the control of pathogenicity. The gene was shown to indirectly regulate the virulence of this bacterium by controlling the gene expression regulatory system of E. coli. The promoter region of the gene's putative target gene was found to be required for this interaction by studying the promoter deletion cerise. Elucidation of this regulatory mechanism of expression may provide new insights into the control of pathogenicity.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

本病原細菌が致死的な食中毒を引き起こすことから、その病原性の解明は、食の安全を守る上で重要な検討になるものと考えられる。また、これまでの検討によって新たに見出された発現制御機構は、病原性の制御に新たな知見をもたらすものと思われる。