Elucidation of the mechanisms for leukemogenesis in Friend-virus infected mice

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07581
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49060:Virology-related
• Research Institution: Kindai University
• Principal Investigator: Tsukamoto Tetsuo 近畿大学, 医学部, 助教 (80750223)
• Co-Investigator(Kenkyū-buntansha): 宮澤 正顯 近畿大学, 医学部, 教授 (60167757)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: フレンド白血病ウイルス / 赤白血病 / 急性骨髄性白血病 / 赤血球前駆細胞

Outline of Final Research Achievements

We here aimed to elucidate better the mechanisms for the onset and maintenance of leukemia. We analyzed murine bone marrow erythroid progenitors and Friend retrovirus (FV)-induced erythroleukemia cells. We first examined the phenotype of the colony-forming subset of erythroid progenitors (CFU-E) and identified several cell surface or intracellular markers. We further sought potential leukemia-associated factors overexpressed in FV-induced leukemia cells compared with normal CFU-E. Among those, we further identified several factors that support the survival and proliferation of leukemia cells. These results contribute to a better understanding of the pathogenesis of leukemia and help better interpret FV-infected mouse models.

Free Research Field

ウイルス学

Academic Significance and Societal Importance of the Research Achievements

急性骨髄性白血病の発症機序については不明な点が多いが、ストレスとの関連が注目され、研究が進められている。その一方で、古くから白血病のマウスモデルとして用いられてきたフレンドウイルス(FV)感染マウスモデルであるが、こちらも貧血や炎症に続発するストレス赤血球産生(stress erythropoiesis)が発症に関わっていることが明らかとなっている。