2021 Fiscal Year Final Research Report
Identification of a novel immune evasion strategy of KSHV based on substrate specificity of ubiquitin ligase
| Project/Area Number |
19K07595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49060:Virology-related
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ウイルス / ユビキチン / ユビキチンリガーゼ / 免疫回避 / カポジ肉腫関連ヘルペスウイルス |
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| Outline of Final Research Achievements |
Kaposi's sarcoma-associated herpesvirus (KSHV) causes malignant tumors in immunocompromised individuals. KSHV expresses viral ubiquitin ligases K3 and K5. Since these ligases mediates ubiquitin-dependent endocytosis of host immunoregulatory molecules, KSHV-infected cells can escape from host immune surveillance. Many membrane proteins have been discovered as substrate for K3 and K5; however, some substrates may remain undiscovered. Based on our knowledge about the substrate specificity of these ligases, we focused several membrane proteins as novel substrate candidate. In this study, L-selectin was identified as novel substrate for K3 and K5.
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| Free Research Field |
微生物学 タンパク質科学
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| Academic Significance and Societal Importance of the Research Achievements |
KSHVユビキチンリガーゼにとっての新たな基質の発見により、これまでに明らかになっていなかった、KSHV感染病態と白血球循環との関連性が浮かび上がってきた。このことは、KSHVによる新たな病態の詳細な解明や、KSHV治療薬の開発等の足掛かりになるかもしれない。
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