Identification of the bone microenvironment that constructs the innate immune system

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07604
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Kyoto University
• Principal Investigator: Hara Takahiro 京都大学, ウイルス・再生医科学研究所, 助教 (90512301)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 骨髄 / ストローマ細胞 / 微小環境

Outline of Final Research Achievements

There are various types of immune cells responsible for innate immunity, and they play an important role in pathological conditions such as infectious immune response, antitumor immunity, and inflammatory diseases. However, it is not clear whether there is diversity in the bone marrow microenvironment that supports the differentiation, maintenance, and response of various innate immune cells. In this study, we found that multiple innate immune cells form a unique positioning within the bone marrow, and that the bone marrow has a "functionally compartmentalized microenvironment" that supports the innate immune cells.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

定常状態においては、骨髄ストローマ細胞がその種類によって異なる自然免疫細胞を支持していることが示唆された。また、慢性炎症疾患などの病態モデルにおいては、自然免疫細胞の誘引・繋留に関与する分子の機能が阻害され、自然免疫細胞の骨髄内での挙動や末梢への動員に変化が起きた。病態時において、骨髄ストローマ細胞の性質が変容する結果が得られたことから、骨髄ストローマ細胞は慢性炎症疾患の治療標的となり得る。