2021 Fiscal Year Final Research Report
Acidic environment of cancer tissues promotes cancer progression
Project/Area Number |
19K07662
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 50010:Tumor biology-related
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
野呂 綾 三重大学, 医学部附属病院, 助教 (00747173)
石飛 真人 三重大学, 医学部附属病院, 准教授 (40443535)
小塚 祐司 三重大学, 医学部附属病院, 講師 (50378311)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 癌細胞 / 酸性環境 / 癌進展 / 癌転移 |
Outline of Final Research Achievements |
An acidic environment in cancer tissues is supposed to promote cancer progression. Breast cancer cells cultured in an acidic medium caused epithelial-mesenchymal transition. Integrin αvβ6 and phosphorylation of FAK/Src were involved in the change. Cortactin phosphorylated in downstream of the kinases was accumulated in adhesion plaques. Formation of cortactin-positive invadepodia promoted cancer cell invasion. Murine breast cancer cells, which were cultured in an acidic medium and injected into tail veins, formed significantly more metastatic foci in the lungs than those in the normal medium. In cancer cells cultured in the acidic condition in human breast cancer tissues, an enhanced expression of molecular markers for acidic condition, such as GLUT1, were confirmed. Now, we are going to clarify a relationship between expression of these markers and patient outcomes using the tissue microarrays.
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Free Research Field |
人体病理学
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、乳癌細胞が酸性条件下で浸潤能を亢進する分子メカニズムを明らかとし、マウスの肺転移モデルで転移浸潤能が亢進していることを確認し、ヒト乳癌組織で実際に酸性条件下が患者の生存率を低くしていることを明らかとしようとしている。これらにより乳癌組織の酸性環境による癌進展の促進というあたらしい切り口を開拓したものであり、従来されてきた癌治療の再考や、今後新たな治療法を開発する上で、新規の観点を提供できる。
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