2021 Fiscal Year Final Research Report
Establishment of novel mouse early breast cancer induction model for studies of breast tumorigenesis and prevention
Project/Area Number |
19K07665
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 50010:Tumor biology-related
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Research Institution | National Cardiovascular Center Research Institute (2021) Foundation for Biomedical Research and Innovation at Kobe (2019-2020) |
Principal Investigator |
Itou Junji 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員 (10638844)
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Co-Investigator(Kenkyū-buntansha) |
笹沼 博之 京都大学, 医学研究科, 准教授 (00531691)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 乳がん / マウスモデル / エストロゲン / 乳がん予防 |
Outline of Final Research Achievements |
To study early breast cancer, we aimed to establish mouse early breast cancer induction model. We successfully observed mammary dysplasia formation, which is also observed in human early breast cancer, when we daily injected E2, a female hormone, to mice having DNA repair deficiency for 30 days. We tested the effects of isoflavones and fermented barley extract in our early breast cancer induction model, and observed the their preventive effects, suggesting that these materials have potentials of breast cancer prevention.
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Free Research Field |
腫瘍学
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、初期の乳がんをマウスで調べる実験系を確立した。それにより、乳がんの発生や初期の現象を研究できるようになった。そして、本研究はその実験系を使い、女性ホルモンのエストロゲンに起因する乳がんではMYC遺伝子が関わっていることを明らかにした。さらに、初期乳がんを抑える物質を探索し、イソフラボン類と発酵大麦エキスに、その可能性があることをみつけた。
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