Analysis of cancer control mechanisms related to cancer and circadian rhythm

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kansai Medical University
• Principal Investigator: MIKI Takao 関西医科大学, 医学部, 講師 (30452345)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: がん / 概日リズム

Outline of Final Research Achievements

We aim to develop new molecular-targeted drugs for cancer. Our approach is to understand cancer regulatory mechanisms from an unprecedented perspective by focusing on the novel association between cancer and circadian rhythms. In this study, we identified a potential novel cancer control mechanism by RB, using the new association between circadian rhythms and the tumor suppressor gene RB that we have previously identified as a basis. We think that detailed investigation of these results is expected to lead to new molecular targets for cancer.

Free Research Field

がん

Academic Significance and Societal Importance of the Research Achievements

がんの新しい分子標的薬を開発するために、がんと概日リズムという新たな関連を題材とすることにより、これまでに無い視点からのがん制御機構の同定を目指している。本研究では、これまでに同定してきた概日リズムとがん抑制遺伝子RBとの新たな関連を基盤として用い、RBによる新規がん制御機構の可能性を同定した。この結果を詳細に検討していくことで、がんの新しい分子標的に繋がることが期待できる。