Investigation of pathological mechanism, and innate immune targeting drug discovery in prion diseas

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K07844
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 51030:Pathophysiologic neuroscience-related
• Research Institution: Fukuoka University (2020-2022); Nagasaki University (2019)
• Principal Investigator: Ishibashi Daisuke 福岡大学, 薬学部, 教授 (10432973)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: Prion / Innate immunity / Interferon

Outline of Final Research Achievements

In this study, we investigated about suppression mechanism via type I interferon system in innate immune responses against prion infection to host. As a result, we defined that low molecular compound and recombinant protein can stimulate type I interferon system in host might inhibit prion infection. Furthermore, we showed that the immune system mediating type I interferon receptor might also suppress infection from prion strain has never been clear in prion-infected mice model. We believe that our achievement in this project might contribute to progress of prevention and drug discovery for prion disease.

Free Research Field

ウイルス学、免疫学、分子生物学

Academic Significance and Societal Importance of the Research Achievements

宿主の自然免疫機構を視点としたプリオン感染病態メカニズムの解明について研究を遂行することにより、免疫学的知見を生かしたプリオン病の創薬開発が進むことが期待される。